Ovarian dysfunction in neonatally thymectomized rats.

Immunologic reactivity in neonatally thymectomized rats receiving competent lymphoid cells during immunization.

Thymectomized Mice Thymus Grafts in Neonatally Tolerance Induction with

Multiplication of Mycobacterium leprae from large inocula in neonatally thymectomized lewis rats.

There is a well recognized need for an experimental animal more s u sceptible to ~. leprae to be used during the course of l e prosy chemotherapy , to detect small numbers of surviving M. leprae in the presence of large numbers of killed ~. leprae. Such an animal must have minimal immunological responsiveness s o that the large numbers of d ead M. leprae will not act as an immunogen, preve ntin...

Homograf t Rejection by Neonatally Thymectomized Germ-free Mice1

A response to tissue transplantation was elicited in germ-free neonatally thymectomized CFW and C3H mice by challenge with homotransplantations of methylcholanthrene-inducecl tumor cells and neoplastic lymph node cells. Germ-free thymectomized mice of both CFW and C3H strains accepted all isologous trans plants and rejected all homologous transplants with only 1 excep tion. When these thymectom...

Neonatally thymectomized Lewis rats infected with Mycobacterium leprae: response to primary infection, secondary challenge, and large inocula.

Several experiments were carried out to measure the ability of neonatally thymectomized Lewis rats (NTLR) to limit multiplication of Mycobacterium leprae. NTLR inoculated in one hind footpad with 10(7) viable M. leprae and challenged in the other hind footpad with 5 x 10(3) organisms simultaneously or 120 or 180 days later permitted multiplication in both sites. By contrast, immunologically int...